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Publication list

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2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
2000 | 1999 | 1998


  1. Yahata, M., Ishii, Y., Nakagawa, T., Watanabe, T., Miyawaki, I., Applicability of the Øie-Tozer model to predict three types of distribution volume (Vd) in humans: Vd in central compartment, Vd at steady state, and Vd at beta phase.
    Biopharm. Drug Dispos., in press.
  2. Miyauchi, Y.*, Kurita, A.*, Yamashita, R., Takamatsu, T., Ikushiro, S., Mackenzie, P. I., Tanaka, Y., Ishii Y., Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT. *Equally contributed to this work
    Biochem. Biophys. Res. Commun., 525: 348-353 (2020).
  3. Fujimoto, K.*, Uchida, S., Amen, R. N. S., Ishii Y., Tanaka, Y., Hirota, Y.*, Lysosomal integral membrane protein LGP85 (LIMP-2) is ubiquitinated at the N-terminal cytoplasmic domain. *Equally contributed to this work
    Biochem. Biophys. Res. Commun., 524: 424-430 (2020).
  4. Miyauchi, Y., Tanaka, Y., Nagata, K., Yamazoe, Y., Mackenzie, P. I., Yamada, H., Ishii Y., UDP-Glucuronosyltransferase (UGT)-Mediated Attenuations of Cytochrome P450 3A4 Activity: UGT Isoform-Dependent Mechanism of Suppression.
    Br. J. Pharmacol., 177: 1077-1089 (2020).


  1. Li, R., Xu, G. H, Cao, J., Liu, B., Xie, H. F., Ishii, Y., Zhang, C. F., Alpha-Mangostin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice Partly Through Activating Adenosine 5'-Monophosphate-Activated Protein Kinase.
    Front. Pharmacol., 10: 1305 (2019).PDF
  2. Miyauchi, Y., Yamada, H., Ishii, Y., Advantage of a Co-expression System for Estimating Physiological Effects of Functional Interaction Between Cytochrome P450 3A4 and Uridine 5’-Diphospho-Glucuronosyltransferase 2B7.
    BPB Rep., 2: 61-66 (2019).PDF
  3. Li. R., Fukumori, R., Takeda, T., Song, Y., Morimoto, S., Kikura-Hanajiri, R., Yamaguchi, T., Watanabe, K., Aritake, K., Tanaka Y., the late Yamada, H., Yamamoto, T., Ishii, Y., Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory.
    Sci. Rep., 9: 9621 (2019).PDF
  4. Miyauchi, Y.*, Kimura, S.*, Kimura, A., Kurohara, K., Hirota, Y., Fujimoto, K., Mackenzie, P. I., Tanaka, Y., Ishii, Y., Investigation of the Endoplasmic Reticulum Localization of UDP-Glucuronosyltransferase 2B7 with Systematic Deletion Mutants. *Equally contributed to this work
    Mol. Pharmacol., 95: 551-562 (2019).PDF
  5. Yahata, M., Ishii, Y., Nakagawa, T., Watanabe, T., Bando, K., Species differences in metabolism of a new antiepileptic drug candidate, DSP-0565 [2-(2'-fluoro[1,1'-biphenyl]-2-yl)acetamide].
    Biopharm. Drug Dispos., 40: 165-175 (2019).


  1. Takeuchi K., Yokouchi C., Goto H., Umehara K., Yamada H., Ishii Y., Alleviation of fatty liver in a rat model by enhancing N1-methylnicotinamide bioavailability through aldehyde oxidase inhibition.
    Biochem. Biophys. Res. Commun., 507: 203-210 (2018).PDF
  2. Hattori Y.*, Takeda T.*, Nakamura A., Nishida K., Shioji Y., Fukumitsu H., Yamada H., Ishii Y., The aryl hydrocarbon receptor is indispensable for dioxin-induced defects in sexually-dimorphic behaviors due to the reduction in fetal steroidogenesis of the pituitary-gonadal axis in rats. *Equally contributed to this work
    Biochem. Pharmacol., 154: 213-221 (2018).


  1. Takeda T.*, Komiya Y.*, Koga T., Ishida T., Ishii Y., Kikuta Y., Nakaya M., Kurose H., Yokomizo T., Shimizu T., Uchi H., Furue M., Yamada H., Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration. *Equally contributed to this work
    J. Biol. Chem. , 292: 10586-10599 (2017).
  2. Kurita, A., Miyauchi, Y., Ikushiro, S., Mackenzie, P. I., Yamada, H., Ishii, Y., Comprehensive characterization of mouse UDP-glucuronosyltransferase (Ugt) belonging to the Ugt2b subfamily: identification of Ugt2b36 as the predominant isoform involved in morphine glucuronidation.
    J. Pharmacol. Exp. Ther., 361: 199-208 (2017).
  3. Li, R., Takeda, T., Ohshima, T., Yamada, H., Ishii, Y., Metabolomic profiling of brain tissues of mouse chronically exposed to heroin.
    Drug Metab. Pharmacokinet., 32: 108-111 (2017).
  4. Takeda, T*., Matsuo, Y*., Nishida, K., Fujiki, A., Hattori, Y., Koga, T., Ishii, Y., Yamada, H., α-Lipoic acid potentially targets AMP-activated protein kinase and energy production in the fetal brain to ameliorate dioxin-produced attenuation in fetal steroidogenesis. *Equally contributed to this work
    J. Toxicol. Sci., 42: 13-23 (2017).


  1. Nakamura, T., Yamaguchi, N., Miyauchi, Y., Takeda, T., Yamazoe, Y., Nagata, K., Mackenzie, P. I., Yamada, H., Ishii, Y., Introduction of an N-glycosylation site into UDP-glucuronosyltransferase 2B3 alters its sensitivity to cytochrome P450 3A1-dependent modulation.
    Front. Pharmacol., 7: 427 (2016).
  2. Uchikawa, T., Kanno, T., Maruyama, I., Mori, N., Yasutake, A., Ishii, Y., Yamada, H., Demethylation of methylmercury and the enhanced production of formaldehyde in mouse liver.
    J. Toxicol. Sci., 41: 479-487 (2016).


  1. Kariyazono, Y., Taura, J., Hattori, Y., Ishii, Y., Narimatsu, S., Fujimura, M., Takeda, T., Yamada, H., Effect of in utero exposure to endocrine disruptors on fetal steroidogenesis governed by the pituitary-gonad axis: a study in rats using different ways of administration.
    J. Toxicol. Sci., 40: 909-916 (2015).
  2. Miyauchi, Y., Nagata, K., Yamazoe, Y., Mackenzie, P. I., Yamada, H., Ishii Y., Suppression of cytochrome P450 3A4 function by UDP-glucuronosyltransferase (UGT) 2B7 through a protein-protein interaction: Cooperative roles of the cytosolic carboxyl-terminal domain and the luminal anchoring region of UGT2B7.
    Mol. Pharmacol.,88: 800-812 (2015).
  3. Kakizuka, S*., Takeda, T*., Komiya, Y., Koba, A., Uchi, H., Yamamoto, M., Furue, M., Ishii, Y., Yamada, H., Dioxin-produced alteration in the profiles of fecal and urinary metabolomes: a change in bile acids and its relevance to toxicity. *Equally contributed to this work
    Biol. Pharm. Bull., 38: 1484-1495 (2015).
  4. Mitoma C, Uchi H, Tsukimori K, Yamada H, Akahane M, Imamura T, Utani A, Furue M., Yusho and its latest findings-A review in studies conducted by the Yusho Group.
    Environ. Int. , 82: 41-48 (2015).
  5. Takeuchi, K, Goto, H, Ito, Y., Sato, M., Matsumoto, S., Senba, T., Yamada, H., Umehara, K., Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet.
    J. Toxicol. Sci. , 40: 181-191 (2015).
  6. Ogura K., Ishii Y., Significance of non-cytochrome P450 (non-P450) enzymes in basic science, clinical field and drug development.
    Drug Metab. Pharmacokinet. , 30: 1-2 (2015).


  1. Taura J*., Takeda T*., Fujii M., Hattori Y., Ishii Y., Kuroki H., Tsukimori K., Uchi H., Furue M., Yamada H., 2,3,4,7,8-Pentachlorodibenzofuran is far less potent than 2,3,7,8-tetrachlorodibenzo-p-dioxin in disrupting the pituitary-gonad axis of the rat fetus. *Equally contributed to this work
    Toxicol. Appl. Pharmacol. , 281: 48-57 (2014).
  2. Yamamiya I., Yoshisue K., Ishii Y., Yamada H., Yoshida K., Species variation in the enantioselective metabolism of tegafur to 5-fluorouracil.
    J. Pharm. Pharmacol. , 66: 1686-1697 (2014).
  3. Mitsui T., Nemoto T., Miyake T., Nagao S., Ogawa K., Kato M., Ishigai M., Yamada H., A useful model capable of predicting the clearance of CYP3A4 substrates in humans: validity of CYP3A4 transgenic mice lacking their own Cyp3a enzymes.
    Drug Metab. Dispos. , 42: 1540-1547 (2014).
  4. Yamamiya I., Yoshisue K., Ishii Y., Yamada H., Chiba M., Effect of cytochrome P450 2A6 genetic polymorphism on the metabolic conversion of Tegafur to 5-fluorouracil and its enantioselectivity.
    Drug Metab. Dispos. , 42: 1485-1492 (2014).
  5. Hattori Y., Takeda T., Fujii M., Taura J., Ishii Y., Yamada H., Dioxin-induced fetal growth retardation: the role of a preceding attenuation in the circulating level of glucocorticoid.
    Endocrine , 47: 572-580 (2014).
  6. Takeda T., Taura J., Hattori Y., Ishii Y., Yamada H., Dioxin-induced retardation of development through a reduction in the expression of pituitary hormones and possible involvement of an aryl hydrocarbon receptor in this defect: a comparative study using two strains of mice with different sensitivities to dioxin.
    Toxicol. Appl. Pharmacol., 278: 220-229 (2014).
  7. Ishii Y., Koba H., Kinoshita K., Oizaki T., Iwamoto Y., Takeda S., Miyauchi Y., Nishimura Y., Egoshi N., Taura F., Morimoto S., Ikushiro S., Nagata K., Yamazoe Y., Mackenzie P. I., Yamada H., Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants.
    Drug Metab. Dispos. , 42: 229-238 (2014).
  8. Takeda T., Fujii M., Hattori Y., Yamamoto M., Shimazoe T., Ishii Y., Himeno M., Yamada H., Maternal exposure to dioxin imprints sexual immaturity of the pups through fixing the status of the reduced expression of expression of hypothalamic gonadotropin-releasing hormone.
    Mol. Pharmacol. , 85: 74-82 (2014).


  1. Yamamiya I, Yoshisue K, Ishii Y, Yamada H., Yoshida K., Enantioselectivity in the cytochrome P450-dependent conversion of tegafur to 5-fluorouracil in human liver microsomes.
    Pharmacol. Res. Perspect. , 1(1) : e00009 (2013).
  2. Takeda T.,Hattori Y.,Fujii M.,Taura J.,Ishii Y.,Yamada H., The gender-specific effect of maternal exposure to dioxin on fetal steroidogenesis in the adrenal gland.
    Fukuoka Igaku Zasshi , 102: 143-151 (2013).
  3. Tsujimoto S., Ishida T., Takeda T., Ishii Y., Onomura Y., Tsukimori K., Takechi S., Yamaguchi T., Uchi H., Suzuki S. O., Yamamoto M., Himeno M., Furue M., Yamada H., Selenium-binding protein 1: Its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
    Biochim. Biophys. Acta , 1830: 3616-3624 (2013).


  1. Ishii Y., An K., Nishimura Y., Yamada H., ATP Serves as an Endogenous Inhibitor of UDP-Glucuronosyltransferase (UGT): A New Insight into the 'Latency' of UGT.
    Drug Metab. Dispos., 40: 2081-2089 (2012).
  2. Ishii Y., Iida N., Miyauchi Y., Mackenzie P.I., Yamada H., Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols.
    Biol. Pharm. Bull., 35: 1811-1817 (2012).
  3. Koga, T., Ishida, T., Takeda, T., Ishii, Y., Uchi, H., Tsukimori, K., Yamamoto, M., Himeno, M., Furue, M., and Yamada, H., Restoration of dioxin-induced damage to fetal steroidogenesis and gonadotropin formation by maternal co-treatment with α-lipoic acid.
    PLoS ONE, 7: e40322 (2012).
  4. Takeda T., Fujii M., Taura J., Ishii Y., Yamada H., Dioxin silences gonadotropin expression in perinatal pups by inducing histone deacetylases: a new insight into the mechanism for the imprinting of sexual immaturity by dioxin.
    J. Biol. Chem., 287: 18440-18450 (2012).
  5. Eyanagi R., Toda A., Imoto M., Uchiyama H., Ishii Y., Kuroki H., Kuramoto Y., Soeda S., Shimeno H., Covalent binding of nitroso-sulfonamides to glutathione S-transferase in guinea pigs with delayed type hypersensitivity.
    Int. Immunopharmacol., 12: 694-700 (2012).


  1. Takeda T., Yamamoto M., Himeno M., Takechi S., Yamaguchi T., Ishida T., Ishii Y., Yamada H., 2,3,7,8-Tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin beta-subunits in a fetal age-specific fashion: A comparative study using cultured pituitaries.
    J. Toxicol. Sci., 36: 221-229 (2011).


  1. Ishii Y., Takeda S., Yamada H., Modulation of UDP-glucuronosyltransferase by protein-protein association.
    Drug Metab. Rev., 42: 140 - 153 (2010).
  2. Ishii Y., Nurrochmad A., Yamada H., Modulation of UDP-glucuronosyltransferase activity by endogenous compounds.
    Drug Metab. Pharmacokinet., 25: 134 - 148 (2010).
  3. Nurrochmad A., Ishii Y., Nakanoh H., Inoue T., Horie T., Sugihara K., Ohta S., Taketomi A., Maehara Y., Yamada H., Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity: A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver.
    Drug Metab. Pharmacokinet., 25: 262-273 (2010).
  4. Ishida T., Matsumoto Y., Takeda T., Koga T., Ishii Y., Yamada H., Distribution of 14C-2,3,7,8-tetrachlorodibenzo-p-dioxin to the brain and peripheral tissues of fetal rats and its comparison with adults., in press.
    J. Toxicol. Sci., 35: 563-569 (2010).
  5. Matsumoto Y., Ishida T., Takeda T., Koga T., Fujii M., Ishii Y., Fujimura Y., Miura D., Wariishi H., Yamada H., Maternal exposure to dioxin reduces hypothalamic but not pituitary metabolome in fetal rats: a possible mechanism for a fetus-specific reduction in steroidogenesis.
    J. Toxicol. Sci., 35: 365-373 (2010).
  6. Roy P., Reavey E., Rayne M., Roy S., Abed El Baky M., Ishii Y., Bartholomew C., Enhanced sensitivity to hydrogen peroxide-induced apoptosis in Evi1 transformed Rat1 fibroblasts due to repression of carbonic anhydrase III.
    FEBS J., 277: 441-452 (2010).


  1. Takeda T., Matsumoto Y., Koga T., Mutoh J., Nishimura Y., Shimazoe T., Ishii Y., Ishida T., and Yamada H., Maternal exposure to dioxin disrupts gonadotropin production in fetal rats and imprints defects in sexual behavior.
    J. Pharmacol. Exp. Ther., 329: 1091-1099 (2009).
  2. Takeda S., Ishii Y., Iwanaga M., Nurrochmad A., Ito Y., Mackenzie P.I., Nagata K., Yamazoe Y., Oguri K., and Yamada H., Interaction of Cytochrome P450 3A4 and UDP-Glucuronosyltransferase 2B7: Evidence for Protein-Protein Association and Possible Involvement of CYP3A4 J-Helix in the Interaction.
    Mol. Pharmacol., 75: 956-964 (2009).
  3. Ishida T., Takeda T., Koga T., Yahata M., Ike A., Kuramoto C., Taketoh J., Hashiguchi I., Akamine A., Ishii Y., and Yamada H., Attenuation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity by resveratrol: a comparative study with different routes of administration.
    Biol. Pharm. Bull.,?32: 876-881 (2009).
  4. Ishida T., Sakai Y., Ishii Y., Furue M., and Yamada H., The accelerated excretion of 2,3,4,7,8-pentachlorodibenzofuran by Cholebine.
    Fukuoka Igaku Zasshi, 100: 210-216 (2009).


  1. Ishida T., Ishizaki M., Tsutsumi S., Ishii Y., and Yamada, H., Piperine, a Pepper Ingredient, Improves a Hepatic Increase in Free Fatty Acids by 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
    J. Health Sci., 54: 551-558 (2008).?(Best Paper Award for 2008)
  2. Ishida T., Kawakami M., Baba H., Yahata M., Mutoh J., Takeda S., Fujita H., Tanaka Y., Ishii Y., and Yamada H., Proteasome affects the expression of aryl hydrocarbon receptor-regulated proteins.
    Environ. Pharmacol. Toxicol., 26: 348-354 (2008).
  3. Wada M., Yokota C., Ogata Y., Kuroda N., Yamada H., and Nakashima K., Sensitive HPLC-fluorescence detection of morphine labeled with DIB-Cl in rat brain and blood microdialysates and its application to the preliminarily study of the pharmacokinetic interaction between morphine and diclofenac.
    Anal. Bioanal. Chem., 391: 1057-1062 (2008).


  1. Nishimura Y., Maeda S., Ikushiro S., Mackenzie P.I., Ishii Y., and Yamada H., Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: structure-effect relationships and evidence for an allosteric mechanism.
    Biochim. Biophys. Acta, 1770: 1557-1566 (2007).
  2. Taketoh J., Mutoh J., Takeda T., Ogishima T., Takeda S., Ishii Y., Ishida T., and Yamada H., Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary.
    Life Sci., 80: 1259 - 1267 (2007).
  3. Matsuda K., Fukuzawa T., Ishii Y., and Yamada H., Color reaction of 3,4-methylenedioxyamphetamines with chromotropic acid: Its improvement and application to the screening of seized tablets.
    Forensic Toxicol., 25: 37-40 (2007).
  4. Ishii Y., Iwanaga M., Nishimura Y., Takeda S.,Ikushiro S., Nagata K., Yamazoe Y., Mackenzie P.I., and Yamada, H., Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): Evidence for the functionally active UGT in P450-UGT complex.
    Drug Metab. Pharmacokinet., 22: 367-376 (2007).


  1. Mutoh J., Taketoh J., Okamura K., Kagawa T., Ishida T., Ishii Y., and Yamada H., Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats.
    Endocrinology, 147: 927 - 936 (2006).
  2. Yamada H., Ishii Y., Yamamoto M., and Oguri K., Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: Research history, evolutionary aspect, relation to tumorigenesis, and mechanism.
    Curr. Drug Metab., 7: 397 - 409 (2006).
  3. Takeda S., Kitajima Y., Ishii Y., Nishimura Y., Mackenzie P.I., Oguri K., and Yamada H., Inhibition of UDP-glucuronosyltransferase 2B7-catalyzed morphine glucuronidation by ketoconazole: Dual mechanisms involving a novel non-competitive mode.?Drug Metab. Dispos., 34:1277-1282 (2006).
  4. Okamura K., Ishii Y., Ikushiro S., Mackenzie P.I., and Yamada H., Fatty acyl-CoA as an endogenous activator of UDP-glucuronosyltransferases.
    Biochem. Biophys. Res. Commun.,?345: 1649???1656 (2006).
  5. Ishida T., Nishimura A., Mutoh J., and Yamada H., Enhancement of dioxin toxicity with anti-stress drug, carbenoxolone, in mice.
    J. Health Sci., 52: 30-35 (2006).
  6. Matsuda K., Asakawa N., Iwanaga M., Gohda A., Fukushima S., Ishii Y., and Yamada H., Conversion of γ-hydroxybutyric acid to a fluorescent derivative: a method for screening.
    Forensic Toxicol., 24: ?41??47 (2006).


  1. Takeda S., Ishii Y., Iwanaga M., Mackenzie P.I., Nagata K., Yamazoe Y., Oguri K., and Yamada H., Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4.
    Mol. Pharmacol., 67: 665 - 672 (2005).
  2. Ishida T., Kan-o S., Mutoh J., Takeda S., Ishii Y., Hashiguchi I., Akamine A., and Yamada H., 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced change in intestinal function and pathology: evidence for the involvement of arylhydrocarbon receptor-mediated alteration of glucose transportation.
    Toxicol. Appl. Pharmacol., 205: 89 - 97 (2005).
  3. Ishii Y., Akazawa D., Aoki Y., Yamada H., and Oguri K., Suppression of carbonic anhydrase III mRNA level by an arylhydrocarbon receptor ligand in primary cultured hepatocytes of rat.
    Biol. Pharm. Bull., 28: 1087 - 1090 (2005).
  4. Ishida T., Hori M., Ishii Y., Oguri K., and Yamada H., Effects of dioxins on stress-responsive system and their relevance to toxicity.
    J. Dermatol. Sci., 1: S105 - S112 (2005).
  5. Yamada H., Ishii Y., and Oguri K., Metabolism of Drugs of Abuse: Its Contribution to the Toxicity and the Inter-Individual Differences in Drug Sensitivity.
    J. Health Sci., 51: 1 - 7 (2005).
  6. Takeda S., Ishii Y., Mackenzie P.I., Nagata K., Yamazoe Y., Oguri K., and Yamada H., Modulation of UDP-Glucuronosyltransferase 2B7 Function by Cytochrome P450s In Vitro: Differential Effects of CYP1A2, CYP2C9 and CYP3A4.
    Biol. Pharm. Bull., 28: 2026 - 2027 (2005).
  7. Ishida T., Naito E., Mutoh J., Takeda S., Ishii Y., and Yamada H., The plant flavonoid, quercetin, reduces some forms of dioxin toxicity by mechanism distinct from aryl hydrocarbon receptor activation, heat-shock protein induction and quenching oxidative stress.
    J. Health Sci.,?51: 410 - 417 (2005).
  8. Eyanagi R., Toda A., Ishii Y., Saito H., Soeda S., Shimeno H., and Shigematsu H., Antigenicity of sulfanilamide and its metabolites using fluorescent-labelled compounds.
    Xenobiotica, 35: 911 - 925 (2005).


  1. Ishii, Y., Miyoshi, A., Maji, D., Yamada, H., and Oguri, K., Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UGT2B21-catalyzed chloramphenicol glucuronidation.
    Drug Metab. Dispos., 32: 1057 - 1060 (2004).
  2. Yamamoto, M., Mise, M., Matsumoto, S., Ito, S., Gohyama, N., Ishida, S., Sagara, Y., Omiecinski, C. J., Oguri, K., and Yamada, H., Comparison of genomic and cDNA sequences of guinea pig CYP2B18 and rat CYP2B2: absence of a phenobarbital-responsive enhancer module in the upstream region of the CYP2B18 gene.
    J. Biochem. Mol. Toxicol., 18: 124 - 130 (2004).
  3. Ishida, T., Taketoh, J., Nakatsune, E., Kan-o, S., Naito, E., Takeda, S., Mutoh, J., Ishii, Y., and Yamada, H., Curcumin anticipates the suppressed body weight gain with 2,3,7,8-tetrachloro-dibenzo-p-dioxin in mice.
    J. Health Sci., 50: 474 - 492 (2004).
  4. Ishida, T., Oshimo, T., Nishimura, A., Mutoh, J., Ishii, Y., Koga, N., Yamada, H., Hashiguchi, I., Akamine A., and Oguri, K., Reducing the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin using the antiulcer drug, geranylgeranylacetone.
    Biol Pharm Bull., 27: 1397 - 1402 (2004).
  5. Taura K., Naito E., Ishii Y., Mori MA., Oguri K., and Yamada H., Cytochrome P450 1A1 (CYP1A1) inhibitor alpha-naphthoflavone interferes with UDP-glucuronosyltransferase (UGT) activity in intact but not in permeabilized hepatic microsomes from 3-methylcholanthrene-treated rats: possible involvement of UGT-P450 interactions.
    Biol Pharm Bull., 27: 56 - 60 (2004).
  6. Ishida, T., Abe, M., Oguri, K., and Yamada, H., Enhancement of acetaminophen cytotoxicity in selenium-binding protein-overexpressed COS-1 cells.
    Drug Metab. Pharmacokinet., 19: 290 - 296 (2004).
  7. Wells P.G., Mackenzie P.I., Roy Chowdhury J., Guillemette C., Gregory P.A., Ishii Y., Hansen A.J., Kessler F.K., Kim P.M., Roy Chowdhury N., and Ritter J.K., Glucuronidation and the UDP-glucuronosyltransferases in health and disease.
    Drug Metab. Dispos., 32: 281 - 290 (2004).


  1. Yamada H., Ishii K., Ishii Y., Ieiri I., Nishino S., Morioka T., and Oguri K., Formation of highly analgesic morphine-6-glucuronide following physiologic concentration of morphine in human brain.
    J. Toxicol. Sci., 28: 395 - 402 (2003).


  1. Taura, K., Yamada, H., Naito, E., Ariyoshi, N., Mori, M., and Oguri, K., Activation of microsomal epoxide hydrolase by interaction with cytochrome P450: kinetic analysis of the association and substrate-specific activation of epoxide hydrolase function.
    Arch. Biochem. Biophys., 402: 275 - 280 (2002).
  2. Yamada, H., Gohyama, N., Honda, S., Hara, T., Harada, N., and Oguri, K., Estrogen-dependent regulation of the expression of hepatic cytochromes P450: assessment using aromatase - deficient mice.
    Toxicol. Appl. Pharmacol., 180: 1 - 10 (2002).
  3. Yamada, H., Yamahara, A., Yasuda, S., Abe, M., Oguri, K., Fukushima, S., and Ikeda-Wada, S., Dansyl chloride derivatization of methamphetamine: a method with advantages for screening and analysis of methamphetamine in urine.
    J. Anal. Toxicol., 26: 17 - 22 (2002).
  4. Ishida, T., Ishii, Y., Yamada, H., and Oguri, K., The induction of hepatic selenium-binding protein by aryl hydrocarbon (Ah)-receptor ligands in rats.
    J. Health Sci., 48: 62 - 68 (2002).
  5. Ishii Y., and Oguri K., Liver proteins that are sensitive to a dioxin-like toxic compound, coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl.
    J. Health Sci., 48: 97 - 105 (2002).


  1. Ishii, Y., Miyoshi, A., Watanabe, R., Tsuruda, K., Tsuda, M., Yamaguchi-Nagamatsu, Y., Yoshisue, K., Tanaka, M., Maji, D., Ohgiya, S., and Oguri, K., Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21- catalyzed morphine-6-glucuronide formation.
    Mol. Pharmacol., 60: 1040 - 1048 (2001).
  2. Ishii,Y., Kato, H., Hatsumura, M., Ishida, T., Ariyoshi, N., Yamada, H., and Oguri, K., Role of the dioxin-like toxic compound coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl in reducing hepatic alcohol dehydrogenase levels in rats in vivo.
    J. Health Sci., 47: 575 - 578 (2001).
  3. Ishii, Y., Kato, H., Hatsumura, M., Ishida, T., Ariyoshi, N., Yamada, H., and Oguri, K., Effects of a highly toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl on intermediary metabolism: reduced triose phosphate content in rat liver cytosol.
    Fkuoka Acta Med., 92: 190 - 200 (2001).
  4. Yoshioka, Y., Ishii, Y., Ishida, T., Yamada, H., Motojima, K., and Oguri, K., Suppression of stress proteins, GRP78, GRP94, Calreticulin and calnexin in liver endoplasmic reticulum of rat treated with a highly toxic coplanar PCB.
    Fukuoka Acta Med., 92: 201 - 216 (2001).


  1. Yamada, H., Matsunaga, H., Tsuji, K., Matsumoto, S., Yamamoto, M., Ishii, Y., Omiecinski, C.J., and Oguri, K. Sequence analyses of CYP2B genes and catalytic profiles for P450s in the Qdj:Sprague-Dawley rats that lack response to the phenobarbital-mediated induction of CYP2B2.
    J. Pharmacol. Exp. Ther., 295: 986 - 993 (2000).
  2. Yamada, H., Yamaguchi, T., and Oguri, K. Suppression of the expression of the CYP2B genes by retinoic acids.
    Biochem. Biophys. Res. Commun., 277: 66 - 71 (2000).
  3. Taura, K., Yamada, H., Hagino, Y., Ishii, Y., Mori, M., and Oguri, K. Interaction between Cytochrome P450 and Other Drug Metabolizing Enzymes: Evidence for an association of CYP1A1 with microsomal epoxide hydrolase and UDP-glucuronosyltransferase.
    Biochem. Biophys. Res. Commun., 273: 1048 - 1052 (2000).
  4. Ikeda, M., Ishii, Y., Kato, H., Akazawa, D., Hatsumura, M., Ishida, T., Matsusue, K., Yamada, H., and Oguri, K. Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl.
    Arch. Biochem. Biophys., 380: 159 - 164 (2000).
  5. Nagano, E., Yamada, H., and Oguri, K. Characteristic glucuronidation pattern of physiologic concentration of morphine in rat brain.
    Life Sci., 67: 2453 - 2464 (2000).


  1. Matsusue, K., Ishii, Y., Ariyoshi, N., and Oguri, K., A highly toxic coplanar polychlorinated biphenyl compound suppresses △5 and △6 desaturase activities which play key roles in arachidonic acid synthesis in rat liver.
    Chem. Res. Toxicol., 12: 1158 - 1165 (1999).
  2. Yamada, H., Matsuki, Y., Yamaguchi, T., and Oguri, K. Effect of a ligand selective for peripheral benzodiazepine receptor on the expression of rat hepatic P450 cytochromes: Assessment of the effect in vivo and in a hepatocyte culture system.
    Drug Metab. Dispos., 27: 1242 - 1247 (1999).
  3. Yamada, H., Ikeda-Wada, S., and Oguri, K. Highly specific and convenient color reaction for methylenedioxymethamphetamine and related drugs using chromotropic acid: its application as a drug screening test.
    J. Health Sci., 45: 303 - 308 (1999).
  4. Ishida, T., Fukuda, A., Yoshioka, Y., Maji, D., Ishii, Y., and Oguri, K., An improved method for the purification and characterization of a 54 kDa protein in rat liver which has recently been identified as a selenium-binding protein.
    J. Health Sci., 45: 203 - 208 (1999).
  5. Tasaki, k., Ishii, Y., Ishida, T., and Oguri, K., Suppression of stress proteins in endoplasmic reticulum in liver cytosol of rats treated with a highly toxic coplanar PCB.
    Fukuoka Acta Med., 90: 251 - 258 (1999).
  6. Fukuda, A., Ishii, Y., Tasaki, K., Matsusue, K., Ishida, T., and Oguri, K., Induction of molecular chaperones HSP70 and HSP90 in rat liver cytosol by a highly toxic coplanar PCB.
    Fukuoka Acta Med., 90: 259 - 271 (1999).


  1. Ariyoshi, N., Iwasaki, M., Kato, H., Tsusaki, S., Hamamura, M., Ichiki, T., and Oguri, K., Highly toxic coplanar PCB126 reduces liver peroxisomal enzyme activities in rats.
    Environ. Toxicol. Pharmacol., 5: 219 - 225 (1998).
  2. Ishida, T., Tasaki, K., Fukuda, A., Ishii, Y., and Oguri, K., Induction of a cytosolic 54 kDa protein in rat liver that is highly homologous to selenium-binding protein.
    Environ. Toxicol. Pharmacol., 6: 249 - 255 (1998).
  3. Koga, N., Kikuichi, N., Kanamaru, T., Kuroki, H., Matsusue, K., Ishida, C., Ariyoshi, N., Oguri, K., and Yoshimura, H., Metabolism of 2,3',4',5-tetrachlorobiphenyl by cytochrome P450 from rats, guinea pigs and hamsters.
    Chemosphere, 37: 1895 - 1904 (1998).
  4. Matsuki, Y., Yamada, H., and Oguri, K. Phenobarbital-mediated induction of CYP2B subfamily is not antogonized by picrotoxin, a potent antagonist of the barbiturate in the central nurvous system.
    Biol. Pharm. Bull., 21: 1160 - 1162 (1998).
  5. Yamada, H., Nakamura, T., and Oguri, K. Induction of CYP2B subfamily by various toxic ingredients in plants: No correlation between toxicity and inducing activity.
    J. Toxicol. Sci., 23: 395 - 402 (1998).
  6. Yamada, H., Ikeda-Wada, S., and Oguri, K. A new screening of amphetamine and methamphetamine using dansyl chloride derivatization and cartridge fluorescence.
    Biol. Pharm. Bull., 21: 778 - 781 (1998).

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